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Whole-Exome Sequencing and cfDNA Analysis Uncover Genetic Determinants of Melanoma Therapy Response in a Real-World Setting.

International journal of molecular sciences - 21 Feb 2023

Vanni Irene, Pastorino Lorenza, Tanda Enrica Teresa, Andreotti Virginia, Dalmasso Bruna, Solari Nicola, Mascherini Matteo, Cabiddu Francesco, Guadagno Antonio, Coco Simona, Allavena Eleonora, Bruno William, Pietra Gabriella, Croce Michela, Gangemi Rosaria, Piana Michele, Zoppoli Gabriele, Ferrando Lorenzo, Spagnolo Francesco, Queirolo Paola, Ghiorzo Paola

Abstract excerpt

Although several studies have explored the molecular landscape of metastatic melanoma, the genetic determinants of therapy resistance are still largely unknown. Here, we aimed to determine the contribution of whole-exome sequencing and circulating free DNA (cfDNA) analysis in predicting response to therapy in a consecutive real-world cohort of 36 patients, undergoing fresh tissue biopsy and followed during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36901733
DOI: 10.3390/ijms24054302
PMCID: PMC10002464

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