Article

Enhanced specificity of high sensitivity somatic variant profiling in cell-free DNA via paired normal sequencing: design, validation, and clinical experience of the MSK-ACCESS liquid biopsy assay

2020-12-07

Abstract excerpt

<title>Abstract</title> <p>Circulating cell-free DNA (cfDNA) from blood plasma of cancer patients can be used to interrogate somatic tumor alterations non-invasively or when adequate tissue is unavailable. We have developed and clinically implemented MSK-ACCESS (Analysis of Circulating cfDNA to Evaluate Somatic Status), an NGS assay for detection of very low frequency somatic alterations in select exons and intro...

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Literature Corpus work: 8be5622b-52b3-5b92-a831-9f3b21638c9e
DOI: 10.21203/rs.3.rs-120695/v1

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