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Integrated <i>in silico</i> and experimental screening identifies novel ligands that target precursor microRNA-31 at the Dicer cleavage site

2025-06-25

Abstract excerpt

MicroRNAs (miRNAs) regulate gene expression and the dysregulation in mature miRNA levels has been implicated in a wide variety of diseases. In particular, altered levels of mature microRNA-31 (miR-31) has been linked to a variety of different cancers. Targeting functionally relevant sites of the precursor structure of miR-31 with small molecules offer a strategy to regulate miR-31 maturation. Herein we describe a...

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Identifiers and source

Literature Corpus work
a440b5d1-5be1-5671-9843-c79cf037549a
DOI
10.1101/2025.06.20.660744
Open publication

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Integrated <i>in silico</i> and experimental screening identifies novel ligands that target precursor microRNA-31 at the Dicer cleavage siteDOI 10.1101/2025.06.20.660744
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