Article

A new dual-affinity peptide nucleic acid for targeting miRNA-21 precursor rescues tumor repressor PTEN expression

2025-08-09

Abstract excerpt

MicroRNAs (miRNAs) have multiple functions in cells and are related to many diseases including cancer by regulating posttranscriptional gene expression. The microRNA precursors (pre-miRs), which can be cleaved by Dicer endonuclease to produce mature miRNAs, often have a cleavage site consisting of both double-stranded (ds) and single-stranded (ss) RNA structures. Peptide nucleic acid (PNA) is a kind of analogue of...

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Literature Corpus work: 4ee0af60-2cf1-5109-9557-4f0adba9a385
DOI: 10.1101/2025.08.08.668835

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