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Cellular senescence: at the nexus between ageing and diabetes

26 Aug 2019

Abstract excerpt

Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular mechanisms, one of which is cellular senescence. The abundance of senescent cells in various tissues increases with age, obesity and diabetes. Senescent cells have been directly implicated in the generation of insulin resistance. Recently, drugs that preferentially target senescent cells, known as senolytics, have been...

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PMID: 31451866
DOI: 10.1007/s00125-019-4934-x

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