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Article

Role of Cellular Senescence in Type II Diabetes.

Endocrinology - 1 Oct 2021

Narasimhan Akilavalli, Flores Rafael R, Robbins Paul D, Niedernhofer Laura J

Abstract excerpt

Cellular senescence is a cell fate that occurs in response to numerous types of stress and can promote tissue repair or drive inflammation and disruption of tissue homeostasis depending on the context. Aging and obesity lead to an increase in the senescent cell burden in multiple organs. Senescent cells release a myriad of senescence-associated secretory phenotype factors that directly mediate pancreatic β-cell...

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Identifiers

PMID: 34363464
DOI: 10.1210/endocr/bqab136
PMCID: PMC8386762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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