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Aging and stress induced β cell senescence and its implication in diabetes development

13 Nov 2019

Abstract excerpt

Cellular senescence is a well-established defensive mechanism for tumor suppression, and is also proposed to play a crucial role in embryonic development, wound repair, aging and age-related diseases. Senescent cell is characterized by the marked morphological changes and active metabolism along with a distinctive senescence associated secretion phenotype (SASP). Cellular senescence is triggered by multiple...

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PMID: 31721726
DOI: 10.18632/aging.102432

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