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Article

Lamin B1 Safeguards the B Cell Genome and Shapes Lymphoma Outcome

2025-11-04

Abstract excerpt

Lamin B1 is a structural component of the nuclear lamina that participates in diverse cellular processes, including genome regulation and cellular senescence. During adaptive immune responses, B lymphocytes in germinal centres (GCs) undergo clonal expansion and programmed DNA damage at immunoglobulin loci, while simultaneously downregulating Lamin B1. Likewise, Lamin B1 downregulation has been observed in GC-deriv...

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Literature Corpus work
a3d7895d-b1de-5c01-9752-5c2344a3884c
DOI
10.1101/2025.11.03.686246
Open publication

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Lamin B1 Safeguards the B Cell Genome and Shapes Lymphoma OutcomeDOI 10.1101/2025.11.03.686246
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