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Article

Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development

29 Jan 2021

Abstract excerpt

BACKGROUND: SLFN11 has recently been reported to execute cancer cells harboring replicative stress induced by DNA damaging agents. However, the roles of SLFN11 under physiological conditions remain poorly understood. Germinal center B-cells (GCBs) undergo somatic hypermutations and class-switch recombination, which can cause physiological genotoxic stress. Hence, we tested whether SLFN11 expression needs to be...

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PMID: 33513156
DOI: 10.1371/journal.pone.0237554

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