Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Primary mediastinal large B-cell lymphoma is characterized by large-scale copy-neutral loss of heterozygosity.

Genes, chromosomes & cancer - 1 Oct 2022

Tuveri Stefania, Debackere Koen, Marcelis Lukas, Dierckxsens Nicolas, Demeulemeester Jonas, Dimitriadou Eftychia, Dierickx Daan, Lefesvre Pierre, Deraedt Karen, Graux Carlos, Michaux Lucienne, Cools Jan, Tousseyn Thomas, Vermeesch Joris Robert, Wlodarska Iwona

Abstract excerpt

Development of primary mediastinal B-cell lymphoma (PMBL) is driven by cumulative genomic aberrations. We discovered a unique copy-neutral loss of heterozygosity (CN-LOH) landscape of PMBL which distinguishes this tumor from other B-cell malignancies, including the biologically related diffuse large B-cell lymphoma. Using single nucleotide polymorphism array analysis we identified large-scale CN-LOH lesions in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomics
Share to Loss of Heterozygosity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, Large B-Cell, Diffuse

Share to Mediastinal Neoplasms

Share to Mutation

Source

Identifiers

PMID: 35611992
DOI: 10.1002/gcc.23069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Primary mediastinal large B-cell lymphoma is characterized by large-scale copy-neutral loss of heterozygosity.PMID 35611992Read ↗

Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade.Semantic proximity Read ↗

Next generation sequencing and the management of diffuse large B-cell lymphoma: from whole exome analysis to targeted therapy.Semantic proximity Read ↗

LYmphoid NeXt-Generation Sequencing (LYNX) Panel: A Comprehensive Capture-Based Sequencing Tool for the Analysis of Prognostic and Predictive Markers in Lymphoid Malignancies.Semantic proximity Read ↗

Catalog of genetic progression of human cancers: non-Hodgkin lymphoma.Semantic proximity Read ↗

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphomaSemantic proximity Read ↗

Genomic Landscape of Primary Mediastinal B-Cell Lymphoma Cell Lines.Semantic proximity Read ↗

Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma.Semantic proximity Read ↗

Surveying the Genomic Landscape of Mantle Cell Lymphoma Indicates the Importance of Multimodal Genomic and Transcriptomic ExplorationSemantic proximity Read ↗

Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing.Semantic proximity Read ↗

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma.Semantic proximity Read ↗

Circulating tumor DNA assisting lymphoma genetic feature profiling and identification.Semantic proximity Read ↗

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.