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Article

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process.

Protein science : a publication of the Protein Society - 1 Jul 2009

Wiltzius Jed J W, Sievers Stuart A, Sawaya Michael R, Eisenberg David

Abstract excerpt

Islet Amyloid Polypeptide (IAPP or amylin) is a peptide hormone produced and stored in the beta-islet cells of the pancreas along with insulin. IAPP readily forms amyloid fibrils in vitro, and the deposition of fibrillar IAPP has been correlated with the pathology of type II diabetes. The mechani...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19475663
DOI: 10.1002/pro.145
PMCID: PMC2775219

Genes

IAPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19475663-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process.PMID 19475663Read ↗

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