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Article

Beta structure motifs of islet amyloid polypeptides identified through surface-mediated assemblies.

Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2011

Mao Xiao-Bo, Wang Chen-Xuan, Wu Xing-Kui, Ma Xiao-Jing, Liu Lei, Zhang Lan, Niu Lin, Guo Yuan-Yuan, Li Deng-Hua, Yang Yan-Lian, Wang Chen

Abstract excerpt

We report here the identification of the key sites for the beta structure motifs of the islet amyloid polypeptide (IAPP) analogs by using scanning tunneling microscopy (STM). Duplex folding structures in human IAPP(8-37) (hIAPP(8-37)) assembly were observed featuring a hairpin structure. The multiplicity in rIAPP assembly structures indicates the polydispersity of the rat IAPP(8-37) (rIAPP(8-37)) beta-like...

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Identifiers

PMID: 22106265
DOI: 10.1073/pnas.1102971108
PMCID: PMC3241769

Genes

IAPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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