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Article

Conformations of islet amyloid polypeptide monomers in a membrane environment: implications for fibril formation.

PloS one - 1 Jan 2012

Duan Mojie, Fan Jue, Huo Shuanghong

Abstract excerpt

The amyloid fibrils formed by islet amyloid polypeptide (IAPP) are associated with type II diabetes. One of the proposed mechanisms of the toxicity of IAPP is that it causes membrane damage. The fatal mutation of S20G human IAPP was reported to lead to early onset of type II diabetes and high tendency of amyloid formation in vitro. Characterizing the structural features of the S20G mutant in its monomeric state...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23133593
DOI: 10.1371/journal.pone.0047150
PMCID: PMC3487734

Genes

IAPP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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