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Article

Tracking the amyloidogenic core of IAPP amyloid fibrils: Insights from micro-Raman spectroscopy.

Journal of structural biology - 1 Aug 2017

Louros Nikolaos N, Tsiolaki Paraskevi L, Baltoumas Fotis A, Chryssikos Georgios D, Gionis Vassilis, Hamodrakas Stavros J, Iconomidou Vassiliki A

Abstract excerpt

Human islet amyloid polypeptide (hIAPP) is the major protein component of extracellular amyloid deposits, located in the islets of Langerhans, a hallmark of type II diabetes. The underlying mechanisms of IAPP aggregation have not yet been clearly defined, although the highly amyloidogenic sequence of the protein has been extensively studied. Several segments have been highlighted as aggregation-prone regions...

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Share to Amyloid
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Islet Amyloid Polypeptide

Share to Molecular Dynamics Simulation

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Source

Identifiers

PMID: 28602716
DOI: 10.1016/j.jsb.2017.06.002

Genes

IAPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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