How Single Site Mutations Can Help Understanding Structure Formation of Amyloid β1-40.

Abstract excerpt

Amyloid fibrils represent the structural endpoint on the energetic (mis)folding landscape of very many proteins. Physiologically, amyloid fibrils are observed as a characteristic hallmark in misfolding diseases often associated with degenerative and neurodegenerative disorders. In the beginning of the scientific discussion, the focus is laid on the fibrillar state, but over the time it becomes increasingly clear...

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• Alzheimer Disease
• Amyloid
• Amyloid beta-Peptides
• Mutation
• Peptide Fragments