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Article

Mutational analysis of preamyloid intermediates: the role of his-tyr interactions in islet amyloid formation.

Biophysical journal - 1 Apr 2014

Tu Ling-Hsien, Serrano Arnaldo L, Zanni Martin T, Raleigh Daniel P

Abstract excerpt

Islet amyloid polypeptide (IAPP or Amylin) is a 37-residue, C-terminally amidated pancreatic hormone, cosecreted with insulin that forms islet amyloid in type 2 diabetes. Islet amyloid formation is complex and characterizing preamyloid oligomers is an important topic because oligomeric intermediates are postulated to be the most toxic species produced during fibril formation. A range of competing models for early...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24703313
DOI: 10.1016/j.bpj.2013.12.052
PMCID: PMC3976524

Genes

IAPP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutational analysis of preamyloid intermediates: the role of his-tyr interactions in islet amyloid formation.PMID 24703313Read ↗

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