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Article

Residue specific effects of human islet polypeptide amyloid on self-assembly and on cell toxicity.

Biochimie - 1 Nov 2017

Khemtemourian Lucie, Guillemain Ghislaine, Foufelle Fabienne, Killian J Antoinette

Abstract excerpt

Type 2 diabetes mellitus is characterized histopathologically by the presence of fibrillary amyloid deposits in the pancreatic islets of Langerhans. Human islet amyloid polypeptide (hIAPP), the 37-residue pancreatic hormone, is the major constituent of these amyloid deposits. The propensity of IAPP to form amyloid fibrils is strongly dependent on its primary sequence. An intriguing example is His at residue 18....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28778718
DOI: 10.1016/j.biochi.2017.07.015

Genes

IAPP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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