Article

Quantitative Systems Pharmacology Analysis of Amyloid Aggregation and Hippocampal Atrophy Trajectories in Alzheimer’s Disease by APOE4 Genotype and Valiltramiprosate/ALZ-801 Treatment

2026-08-24

Abstract excerpt

<title>Abstract</title> <p>Apolipoprotein E4 (APOE4) is a major risk factor for Alzheimer’s disease (AD). Valiltramiprosate/ALZ-801, an oral inhibitor of β-amyloid (Aβ) oligomer formation, was evaluated in APOE4/4 subjects with early AD in the APOLLOE4 Phase 3 trial. We used quantitative systems pharmacology (QSP) to characterize AD trajectories by APOE genotype and assess the effects of valiltramiprosate treatme...

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Literature Corpus work: 90229a3d-e53f-5c83-b1c3-2f3c338bd765
DOI: 10.21203/rs.3.rs-10570608/v1

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Quantitative Systems Pharmacology Analysis of Amyloid Aggregation and Hippocampal Atrophy Trajectories in Alzheimer’s Disease by APOE4 Genotype and Valiltramiprosate/ALZ-801 TreatmentDOI 10.21203/rs.3.rs-10570608/v1Read

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