Article
Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.
Current opinion in cell biology - 1 Dec 2010
Pavelka Norman, Rancati Giulia, Li Rong
Abstract excerpt
When cells in our body change their genome and develop into cancer, we blame it on genome instability. When novel species conquer inhospitable environments, we credit it to genome evolution. From a cellular perspective, however, both processes are outcomes of the same fundamental biological properties-genome and pathway plasticity and the natural selection of cells that escape death and acquire growth advantages....
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