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Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor development

15 Apr 2025

Abstract excerpt

Abstract Organismal aging has been associated with diverse metabolic and functional changes across tissues. Within the immune system, key features of physiological hematopoietic cell aging include increased fat deposition in the bone marrow, impaired hematopoietic stem and progenitor cell (HSPC) function, and a propensity towards myeloid differentiation. This shift in lineage bias can lead to pre-malignant bone...

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PMID: 40232347
DOI: 10.1007/s11357-025-01594-w

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