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Article

Cell intrinsic alterations underlie hematopoietic stem cell aging

20 Jun 2005

Abstract excerpt

Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the mechanisms underlying hematopoietic aging, we evaluated the cell intrinsic functional and molecular properties of highly purified long-term hematopoietic stem cells (LT-HSCs) from young and old mice. We found that LT-HSC aging...

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PMID: 15967997
DOI: 10.1073/pnas.0503280102

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