Article

β-Amyloid Protein Induces Mitophagy-Dependent Ferroptosis Through the CD36/PINK/PARKIN Pathway Leading to Blood-Brain Barrier Destruction in Alzheimer's Disease

2021-12-09

Abstract excerpt

<title>Abstract</title> <p>Background Blood-brain barrier (BBB) dysfunction may occur in the onset of Alzheimer's disease (AD). While pericytes are a vital part of the neurovascular unit and the BBB, acting as the gatekeeper of the BBB. Amyloid β (Aβ) deposition and neurofibrillary tangles in the brain are the central pathological features of AD. CD36 promotes vascular amyloid deposition and leads to vascular br...

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Literature Corpus work: 359b0e76-87ab-5f64-9784-d42e5b60347d
DOI: 10.21203/rs.3.rs-1087555/v1

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