Article

Senile plaques in Alzheimer’s disease arise from Aβ and Cathepsin D-enriched amyloidogenic mixtures out of intravascular hemolysis and Charcot-Bouchard aneurysm-related vascular degeneration

2020-05-19

Abstract excerpt

The mechanism governing senile plaque generation in Alzheimer’s disease (AD) remains intensively debated. We analyzed AD brain tissues with histochemistry, immunohistochemistry and fluorescence imaging. We found little co-expression between neural markers and plaque Aβ while abundant co-expression between blood or plasma markers such as HBA, HbA1C, Hemin, ApoE and plaque Aβ. The cores of dense-core plaques were st...

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Literature Corpus work: 7c562cce-601c-51a1-8b1c-02b1d1588b73
DOI: 10.1101/2020.05.17.100941

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