Article

Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization and hemorrhage is a major defect in Alzheimer’s disease

2024-06-11

Abstract excerpt

<h4> Abstract </h4> Alzheimer’s disease (AD) is a multi-amyloidosis disease with Aβ deposits in the cerebral blood vessels, microaneurysms and senile plaques. How Aβ amyloidosis affects axon pathology is not well-examined. We studied Aβ-related axonal phenotypes with histochemistry, immunohistochemistry and fluorescence imaging methods. Widespread axonal amyloidosis with distinctive axonal enlargement was observ...

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Literature Corpus work: 464a39dd-7cb7-51f4-a9b1-67ec82c3fac8
DOI: 10.1101/2024.06.10.598057

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