Article
The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease.
Neuroscience - 1 Jan 2001
Dickson T C, Vickers J C
Abstract excerpt
We have utilised laser confocal microscopy to categorise beta-amyloid plaque types that are associated with preclinical and end-stage Alzheimer's disease and to define the neurochemistry of dystrophic neurites associated with various forms of plaques. Plaques with a spherical profile were defined as either diffuse, fibrillar or dense-cored using Thioflavin S staining or immunolabelling for beta-amyloid. Confocal...
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