Article

Penalised regression improves imputation of cell-type specific expression using RNA-seq data from mixed cell populations compared to domain-specific methods

2023-09-13

Abstract excerpt

Gene expression studies often use bulk RNA sequencing of mixed cell populations because single cell or sorted cell sequencing may be prohibitively expensive. However, mixed cell studies may miss expression patterns that are restricted to specific cell populations. Computational deconvolution can be used to estimate cell fractions from bulk expression data and infer average cell-type expression in a set of samples...

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Literature Corpus work: a3a01bf0-1383-5d49-babd-7e287c9fd1ca
DOI: 10.1101/2023.09.11.556650

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