Article

Estimating the effect of tissue- and blood-derived cell reference matrices on deconvolving bulk transcriptomic datasets

2025-01-27

Abstract excerpt

<h4>Background</h4> Cell deconvolution is a method used to characterize the composition of the mixed cell population in bulk transcriptomic datasets. Tissue- and blood-derived cell reference matrices (CRMs) are typically used, but their impact on deconvolution has yet to be evaluated. <h4>Methods</h4> Recursive feature elimination and random forest methods were applied to build tissue- and blood-derived CRMs usi...

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Literature Corpus work: d4ff4eab-587f-5c01-aefa-cfd52e376334
DOI: 10.1101/2025.01.24.634725

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