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HArmonized single-cell RNA-seq Cell type Assisted Deconvolution (HASCAD)

31 Oct 2023

Abstract excerpt

BACKGROUND: Cell composition deconvolution (CCD) is a type of bioinformatic task to estimate the cell fractions from bulk gene expression profiles, such as RNA-seq. Many CCD models were developed to perform linear regression analysis using reference gene expression signatures of distinct cell types. Reference gene expression signatures could be generated from cell-specific gene expression profiles, such as...

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PMID: 37907883
DOI: 10.1186/s12920-023-01674-w

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