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Improved cell composition deconvolution method of bulk gene expression profiles to quantify subsets of immune cells

1 Dec 2019

Abstract excerpt

BACKGROUND: To facilitate the investigation of the pathogenic roles played by various immune cells in complex tissues such as tumors, a few computational methods for deconvoluting bulk gene expression profiles to predict cell composition have been created. However, available methods were usually developed along with a set of reference gene expression profiles consisting of imbalanced replicates across different...

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PMID: 31856824
DOI: 10.1186/s12920-019-0613-5

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