Article

LXR alters CD4 <sup>+</sup> T cell function through direct regulation of glycosphingolipid synthesis

2019-07-31

Abstract excerpt

The liver X receptor (LXR) is a key transcriptional regulator of cholesterol, fatty acid, and phospholipid metabolism. Dynamic remodeling of immunometabolic pathways, including lipid metabolism, is a crucial step in T cell activation. Here we explored the role of LXR-regulated metabolic processes in primary human CD4 + T cells, and their role in controlling plasma membrane lipids (glycosphingolipids and cholester...

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Literature Corpus work: a39f67d6-56fb-53fd-9603-543889450656
DOI: 10.1101/721050

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