Article

Cholesterol metabolism drives regulatory B cell function

2020-01-03

Abstract excerpt

<h4>Summary</h4> Regulatory B cells restrict immune and inflammatory responses across a number of contexts. This capacity is mediated primarily through the production of IL-10. Here we demonstrate that the induction of a regulatory program in human B cells is dependent on a metabolic priming event driven by cholesterol metabolism. Synthesis of the metabolic intermediate geranylgeranyl pyrophosphate (GGPP) was req...

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Literature Corpus work: 89223a1f-5ecc-5207-90b1-d20a807824d2
DOI: 10.1101/2020.01.03.893982

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