Article
Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation.
PloS one - 1 Jan 2013
Cheng Hsin-Yuan, Wu Runpei, Gebre Abraham K, Hanna Richard N, Smith Dan J, Parks John S, Ley Klaus, Hedrick Catherine C
Abstract excerpt
Gammadelta (γδ) T lymphocytes respond quickly upon antigen encounter to produce a cytokine response. In this study, we sought to understand how functions of γδ T cells are differentially regulated compared to αβ T cells. We found that cholesterol, an integral component of the plasma membrane and a regulator of TCR signaling, is increased in γδ T cells compared to αβ T cells, and modulates their function. Higher...
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