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Article

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages

2018-02-11

Abstract excerpt

<h4>ABSTRACT</h4> Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models. Most synthetic LXR agonists also cause marked hypertriglyceridemia by inducing the expression of SREBP1c and downstream genes that drive fatty acid biosynthesis. Recent studies demonstrated that desmosterol, an intermediate in the cholesterol...

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Literature Corpus work
0472ccfd-7240-5e9b-89e9-aa57e4a28629
DOI
10.1101/263434
Open publication

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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophagesDOI 10.1101/263434
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