Article
LDL receptor-mediated lipoprotein uptake fuels human CD4+ T cell polarization toward a c-MAF/IL-10- and FOXP3-driven phenotype.
JCI insight - 8 Jun 2026
Markovska Angela, van Heusden Niels S, Duijzer Dagmar, Bodelón Alejandra, Rogani Greta, Mocholi Enric, Stigter Edwin Ca, Gulersonmez Can, Kooijman Sander, Van der Zee Leonie, Mulder Monique T, Roeters van Lennep Jeanine E, Rensen Patrick Cn, van Loosdregt Jorg, Vastert Sebastiaan J, Zelcer Noam, Boes Marianne, Schipper Henk S
Abstract excerpt
Human CD4+ T cells utilize nutrients, including lipids, to support their activation and polarization. Considering the pivotal role of lipoproteins in lipid transport, we reasoned that lipoprotein uptake and processing could effect CD4+ T cell function. Here, we demonstrate that activation of human CD4+ T cells induced expression of LDL receptor (LDLR) to facilitate LDLR-mediated endocytosis of LDL. Degradation of...
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