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Article

Cellular and molecular bases of refractory celiac disease.

International review of cell and molecular biology - 1 Jan 2021

Soderquist Craig R, Bhagat Govind

Abstract excerpt

Refractory celiac disease (RCD) encompasses biologically heterogeneous disorders that develop in a small proportion (0.3%) of individuals with celiac disease that are associated with high morbidity. Two broad categories are currently recognized, type I (RCD I) and type II (RCD II), based on immunophenotypic and molecular features of the intraepithelial lymphocytes (IELs). RCD I is characterized by a polyclonal...

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Celiac Disease
Environment
Epigenesis, Genetic
Genetic Predisposition to Disease
Immunophenotyping

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PMID: 33707055
DOI: 10.1016/bs.ircmb.2020.12.001

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