Article

Epigenomic signature of the progeroid Cockayne syndrome exposes distinct and common features with physiological ageing

2021-05-24

Abstract excerpt

Cockayne syndrome (CS) and UV-sensitivity syndrome (UVSS) are rare genetic disorders caused by mutation of the DNA repair and chromatin remodelling proteins CSA or CSB, but only CS patients display a progeroid and neurodegenerative phenotype. As epigenetic modifications constitute a well-established hallmark of ageing, we characterized genome-wide DNA methylation (DNAm) of fibroblasts from CS versus UVSS patients...

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Literature Corpus work: a388e90c-5303-52ce-bc89-03fedc009683
DOI: 10.1101/2021.05.23.445308

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