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Lessons learned from DNA repair defective syndromes

21 May 2007

Abstract excerpt

Genomic instability is the driving force behind cancer development. Human syndromes with DNA repair deficiencies comprise unique opportunities to study the clinical consequences of faulty genome maintenance leading to premature aging and premature cancer development. These syndromes include chromosomal breakage syndromes with defects in DNA damage signal transduction and double-strand break repair, mismatch...

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PMID: 17518994
DOI: 10.1111/j.1600-0625.2007.00559.x

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