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Article

A novel role for CSA in the regulation of nuclear envelope integrity: uncovering a non-canonical function.

Life science alliance - 1 Nov 2024

Yang Denny, Lai Austin, Davies Amelie, Janssen Anne Fj, Ellis Matthew O, Larrieu Delphine

Abstract excerpt

Cockayne syndrome (CS) is a premature ageing condition characterized by microcephaly, growth failure, and neurodegeneration. It is caused by mutations in ERCC6 or ERCC8 encoding for Cockayne syndrome B (CSB) and A (CSA) proteins, respectively. CSA and CSB have well-characterized roles in transcription-coupled nucleotide excision repair, responsible for removing bulky DNA lesions, including those caused by UV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39209536
DOI: 10.26508/lsa.202402745
PMCID: PMC11361374

Genes

CS
ERCC6
ERCC8
LEMD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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