Article

Role of Cockayne Syndrome B (CSB) Protein in Genome Maintenance in Human Cells under Oxidative Stress

2025-01-03

Abstract excerpt

Cockayne Syndrome (CS), a disorder marked by premature ageing and neurodevelopmental abnormalities, is primarily caused by mutations in the CSB protein, a critical component of the transcription-coupled repair pathway of nucleotide excision repair. This study explores the role of CSB in managing oxidative DNA damage and maintaining telomere integrity under oxidative stress conditions. We subjected CSB-deficient hu...

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Literature Corpus work: 72577821-d5b5-5ac4-806e-d740f7a97f81
DOI: 10.1101/2025.01.02.631021

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