Epigenetics, DNA damage, and aging.

doi:10.1172/JCI158446

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Article

Epigenetics, DNA damage, and aging.

The Journal of clinical investigation - 15 Aug 2022

Soto-Palma Carolina, Niedernhofer Laura J, Faulk Christopher D, Dong Xiao

Abstract excerpt

Over the course of a human lifespan, genome integrity erodes, leading to an increased abundance of several types of chromatin changes. The abundance of DNA lesions (chemical perturbations to nucleotides) increases with age, as does the number of genomic mutations and transcriptional disruptions caused by replication or transcription of those lesions, respectively. At the epigenetic level, precise DNA methylation...

Topics

Aging
Chromatin
DNA Damage
DNA Methylation
Epigenesis, Genetic
Genomic Instability
Histones
Humans
Mutation
Signal Transduction
Stochastic Processes

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Open in PubMed Open full text

Identifiers

PMID: 35968782
DOI: 10.1172/JCI158446
PMCID: PMC9374376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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