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A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory mice

2021-07-10

Abstract excerpt

SARS-CoV-2 has infected almost 200 million humans and caused over 4 million deaths worldwide. Evaluating countermeasures and improving our understanding of COVID-19 pathophysiology require access to animal models that replicate the hallmarks of human disease. Mouse infection with SARS-CoV-2 is limited by poor affinity between the virus spike protein and its cellular receptor ACE2. We have developed by serial passa...

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Identifiers and source

Literature Corpus work
164c2163-5b64-5a83-a134-ed7cff1b0927
DOI
10.1101/2021.07.10.451880
Open publication

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A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory miceDOI 10.1101/2021.07.10.451880
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