Article
The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation.
PLoS genetics - 1 Oct 2014
Warnhoff Kurt, Murphy John T, Kumar Sandeep, Schneider Daniel L, Peterson Michelle, Hsu Simon, Guthrie James, Robertson J David, Kornfeld Kerry
Abstract excerpt
The insulin/IGF-1 signaling pathway plays a critical role in stress resistance and longevity, but the mechanisms are not fully characterized. To identify genes that mediate stress resistance, we screened for C. elegans mutants that can tolerate high levels of dietary zinc. We identified natc-1, which encodes an evolutionarily conserved subunit of the N-terminal acetyltransferase C (NAT) complex. N-terminal...
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