Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses.

Cell metabolism - 1 Dec 2006

Liang Bin, Moussaif Mustapha, Kuan Chih-Jen, Gargus J Jay, Sze Ji Ying

Abstract excerpt

Stress response is a fundamental form of behavioral and physiological plasticity. Here we describe how serotonin (5HT) governs stress behavior by regulating DAF-2 insulin/IGF-1 receptor signaling to the DAF-16/FOXO transcription factor at the nexus of development, metabolism, immunity, and stress responses in C. elegans. Serotonin-deficient tph-1 mutants, like daf-2 mutants, exhibit DAF-16 nuclear accumulation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Fluoxetine
Share to Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurosecretory Systems

Share to Receptor, IGF Type 1

Share to Receptor, Insulin

Share to Selective Serotonin Reuptake Inhibitors

Share to Serotonin

Source

Identifiers

PMID: 17141627
DOI: 10.1016/j.cmet.2006.11.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses.PMID 17141627Read ↗

DAF-16: FOXO in the Context of C. elegans.Semantic proximity Read ↗

Neuronal functions of FOXO/DAF-16Semantic proximity Read ↗

DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs.Semantic proximity Read ↗

Acute-stress impairs cytoprotective mechanisms through neural inhibition of the insulin pathwaySemantic proximity Read ↗

DAF-16 target genes that control C. elegans life-span and metabolism.Semantic proximity Read ↗

Starvation-induced changes in somatic insulin/IGF-1R signaling drive metabolic programming across generationsSemantic proximity Read ↗

Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Divergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/insulin/IGF-receptor pathway.Semantic proximity Read ↗

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.Semantic proximity Read ↗

Serotonin's SOS signal.Semantic proximity Read ↗

Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans.Semantic proximity Read ↗

Octopamine enhances oxidative stress resistance through the fasting-responsive transcription factor DAF-16/FOXO in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.