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Article

Dynamic chromatin regulatory landscape of human CAR T cell exhaustion

20 Jul 2021

Abstract excerpt

Significance T cell exhaustion is a major barrier to cancer immunotherapy. T cell exhaustion is the state of T cell dysfunction after chronic stimulation, and recent studies indicate that exhaustion is epigenetically controlled and associated with unique chromatin profiles. This work reports the genome-wide map of active DNA regulatory elements and their connection to genes in the time course of human chimeric...

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PMID: 34285077
DOI: 10.1073/pnas.2104758118

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