Article

Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancer

2021-07-12

Abstract excerpt

Immunotherapy has changed cancer treatment with major clinical successes, but response rates remain low due in part to elevated prevalence of dysfunctional, terminally exhausted T cells. However, the mechanisms promoting progression to terminal exhaustion remain undefined. We profiled the histone modification landscape of tumor-infiltrating CD8 T cells throughout differentiation, finding terminally exhausted T cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 880ac096-213b-5fbd-9501-4912cdf816b0
DOI: 10.1101/2021.07.11.451947

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Altered costimulatory signals and hypoxia support chromatin landscapes limiting the functional potential of exhausted T cells in cancerDOI 10.1101/2021.07.11.451947Read

Fundamentals to therapeutics: Epigenetic modulation of CD8+ T Cell exhaustion in the tumor microenvironmentSemantic proximity Read

Decoding and overcoming T cell exhaustion: Epigenetic and transcriptional dynamics in CAR-T cells against solid tumorsSemantic proximity Read

Deciphering the role of histone modifications in memory and exhausted CD8 T cellsSemantic proximity Read

Dynamic chromatin regulatory landscape of human CAR T cell exhaustionSemantic proximity Read

Hierarchical transcriptional network governing heterogeneous T cell exhaustion and its implications for immune checkpoint blockadeSemantic proximity Read

Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assaySemantic proximity Read

Exhaustion-associated regulatory regions in CD8 + tumor-infiltrating T cellsSemantic proximity Read

Degradation of IKAROS prevents epigenetic progression of T cell exhaustion in a novel antigen-specific assaySemantic proximity Read

Dynamic chromatin regulatory landscape of human CAR T cell exhaustionSemantic proximity Read

Reinvigorating exhausted CD8 + cytotoxic T lymphocytes in the tumor microenvironment and current strategies in cancer immunotherapySemantic proximity Read

Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapySemantic proximity Read