Article
Beyond the Powerhouse: Mitochondrial Crosstalk as a Master Regulator of Cardiac Metabolic Homeostasis and Failure.
Journal of cardiovascular translational research - 28 May 2026
Kang Yu-Xin, Hu Yue, Sun Xi-Tong, Fan Xin-Biao, Li Ao-Lin, Shang Wen-Yu, Jia Yun-Feng, Zhao Yi-Xuan, Wei Miao-Miao, Wang Tian-Qi, Zhang Zheng, Zhu Bo-Yu, Liang Yong-Chun, Zhang Jun-Ping
Abstract excerpt
Mitochondrial dysfunction has long been recognized as a central driver of heart failure (HF) pathogenesis, and emerging evidence highlights that impaired mitochondrial communication, rather than merely energy metabolism dysfunction, plays a pivotal role in the initiation and progression of HF. These communication networks are critical for maintaining cardiac metabolic homeostasis, and their disruption in HF leads...
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