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The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age

2024-10-31

Abstract excerpt

<h4>ABSTRACT</h4> Aging-related decreases in cardiac and skeletal muscle function are strongly associated with various comorbidities. Elamipretide (ELAM), a novel mitochondrial-targeted peptide, has demonstrated broad therapeutic efficacy in ameliorating disease conditions associated with mitochondrial dysfunction across both clinical and pre-clinical models. ELAM is proposed to restore mitochondrial bioenergetic...

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Literature Corpus work
a333232d-3587-5037-8751-881bc8f495ba
DOI
10.1101/2024.10.30.620676
Open publication

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