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Article

Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice.

Aging cell - 1 Jun 2020

Roh Jason D, Houstis Nicholas, Yu Andy, Chang Bliss, Yeri Ashish, Li Haobo, Hobson Ryan, Lerchenmüller Carolin, Vujic Ana, Chaudhari Vinita, Damilano Federico, Platt Colin, Zlotoff Daniel, Lee Richard T, Shah Ravi, Jerosch-Herold Michael, Rosenzweig Anthony

Abstract excerpt

Heart failure with preserved ejection fraction (HFpEF) is the most common type of HF in older adults. Although no pharmacological therapy has yet improved survival in HFpEF, exercise training (ExT) has emerged as the most effective intervention to improving functional outcomes in this age-related disease. The molecular mechanisms by which ExT induces its beneficial effects in HFpEF, however, remain largely...

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Identifiers

PMID: 32441410
DOI: 10.1111/acel.13159
PMCID: PMC7294786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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