Article

The essential inter-domain interaction between NUDT9H and channel domain of human TRPM2 is also accomplished in trans

2023-06-22

Abstract excerpt

Channel function of human transient receptor potential melastatin type 2 (hsTRPM2) essentially depends on its C-terminal domain NUDT9H, which is homologous to the human Nudix hydrolase NUDT9. This cytosolic enzyme specifically binds and cleaves adenosine 5′-diphosphate ribose (ADPR), which in turn represents the principal agonist of TRPM2. For hsTRPM2 the experimental data strongly suggest, that binding of ADPR to...

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Literature Corpus work: a3300543-e10e-538c-8b7c-2af758a4d5cd
DOI: 10.1101/2023.06.21.545868

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