Article

A remarkable case of conserved domain swapping in the COMMD family of proteins

2026-02-04

Abstract excerpt

<h4>ABSTRACT</h4> The eukaryotic COMMD family of proteins are core subunits of the Commander protein complex, with a central role in endosomal membrane trafficking and signalling. Previous crystal and cryoEM structures show that COMMD and COMMD-like proteins form homo-oligomeric and hetero-decameric assemblies with a central ring structure formed by their small C-terminal COMM domains. Their α-helical N-terminal...

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Literature Corpus work: 1c3476f1-d85c-5caa-87c8-5facd5724ea3
DOI: 10.64898/2026.02.02.703414

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